June 11, 2021 – A brand new Cleveland Clinic-led examine has recognized mechanisms by which COVID-19 can result in Alzheimer’s disease-like dementia. The findings point out an overlap between COVID-19 and mind adjustments widespread in sufferers with Alzheimer’s.
Cleveland Clinic says the findings could assist inform threat administration and therapeutic methods for COVID-19-associated cognitive impairment.
Stories of neurological issues in COVID-19 sufferers and “long-hauler” sufferers whose signs persist after the an infection clears have gotten extra widespread, suggesting that SARS-CoV-2 could have lasting results on mind operate, however it’s not but effectively understood how the virus results in neurological points.
Researchers discovered little proof that the virus targets the mind instantly, however they did uncover shut community relationships between the virus and genes/proteins related to a number of neurological ailments, pointing to pathways by which COVID-19 may result in Alzheimer’s disease-like dementia.
To discover this additional, they investigated potential associations between COVID-19 and neuroinflammation and mind microvascular damage, that are each hallmarks of Alzheimer’s.
“We found that SARS-CoV-2 an infection considerably altered Alzheimer’s markers implicated in mind irritation and that sure viral entry elements are extremely expressed in cells within the blood-brain barrier,” defined Dr. Cheng. “These findings point out that the virus could impression a number of genes or pathways concerned in neuroinflammation and mind microvascular damage, which may result in Alzehimer’s disease-like cognitive impairment.”
The researchers additionally discovered that people with the best genetic threat issue for Alzheimer’s had decreased potential to naturally struggle viral infections, which may make these sufferers extra vulnerable to COVID-19.